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Wednesday, July 29, 2020 | History

2 edition of Studies on in-vitro activation of human B cells found in the catalog.

Studies on in-vitro activation of human B cells

Menno Alexander de Rie

Studies on in-vitro activation of human B cells

by Menno Alexander de Rie

  • 115 Want to read
  • 38 Currently reading

Published .
Written in English

    Subjects:
  • B cells -- Differentiation -- Molecular aspects.,
  • Lymphocyte transformation.

  • Edition Notes

    Statementdoor Menno Alexander de Rie.
    The Physical Object
    Paginationiii, 188 p. :
    Number of Pages188
    ID Numbers
    Open LibraryOL18111814M

    Model systems of myometrium that are in a state of flux have the capacity to confound results when researchers seek to elucidate the trigger(s) for labor. This chapter describes in detail, methods and model systems used to study pregnant human uterine smooth muscle, and explores the challenges associated with these model : Marina Ilicic, Jonathan W. Paul. Background: CD40 is expressed on B-cells, monocytes, dendritic cells, other normal tissues and tumors. Previous studies showed that CD40 stimulation enhances antigen presentation, breaks tolerance, bypasses T-cell help, and induces apoptosis in CD40pos tumor cells. We report the in vitro activity and primate pharmacokinetics of a human anti-CD40 agonist antibody, CP Cited by: 9.

    @article{osti_, title = {Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells}, author = {Person, Rachel J. and Tokar, Erik J. and Xu, Yuanyuan and Orihuela, Ruben and Ngalame, Ntube N. Olive and Waalkes, Michael P., E-mail: [email protected]}, abstractNote = {Cadmium is a known human lung carcinogen. In humans, gamma-delta T cells express CD and ICOS upon in vitro activation, a subset of gamma-delta T cells with a Tfh profile are found in blood and tonsils, and patients with alpha-beta T cell deficiencies and elevated levels of gamma-delta T cells have normal levels of Igs ().

    Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism. This is not to be confused with experiments done in vitro ("within the glass"), i.e., in a.   The morphological diversity and cell surface protein heterogeneity of endothelial cells (ECs) in different organs of the body is known since the early s 1, Cited by: 4.


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Four review papers and contributions.

Four review papers and contributions.

Studies on in-vitro activation of human B cells by Menno Alexander de Rie Download PDF EPUB FB2

Kanaga Sabapathy, in Progress in Molecular Biology and Translational Science, C Transient Versus Constitutive JNK Activation. In vitro studies have shown that JNK activation can be transient, often leading to cellular survival signals, compared to sustained activation, often leading to cell death.

One potential reason why the inhibition of the JNK pathway, though. Numerous studies have shown that polyphenols modulate MAPKs (e.g., JNK, ERK, and p38 MAPK) by acting at several steps of the activation cascade.

45 It has been reported that quercetin inhibits iNOS expression through inhibition of p38 MAPK and that it blocks AP-1 binding in LPS-induced RAW cells by inhibiting JNK.

Data from LPS. The expression of surface immunoglobulin (SIg) and la, the classical surface markers of B cells, has been extensively studied during in vitro stimulation. Upon activation, resting B cells which express IgM and/or IgD will lose SIgD, and then no longer express membrane Ig or switch to the expression of other isotypes (1).Cited by: 8.

Mesenchymal stem cells (MSCs) are emerging as key players in regenerative medicine for the treatment of various diseases associated with the inflammation and degeneration, thereby aiding in therapeutic advancements. Several tissues have been identified as potential sources of MSCs including the bone marrow, cord blood, dental pulp, umbilical cord, adipose tissue, peripheral Cited by: 2.

In vitro production of RBCs: the 2-step erythroid culture system. This complex process of erythropoiesis, consisting of progressive phases of 1) progenitor expansion, 2) precursor amplification and maturation, and 3) reticulocyte remodeling into terminal RBCs, has been modeled with varying success in vitro (Figure 1A).The ability to differentiate erythroid cells in Cited by: 2.

*There are literature reports (compiled in reference 26) showing that, in some studies but not in others, cyclophosphamide can be clastogenic in vitro in the absence of metabolic activation. Previous studies have demonstrated that the in vitro stimulation of human B cells by TLRs is an efficient way of inducing the activation and proliferation of these cells, irrespective of BCR specificity (Bernasconi et al., ; Pinna et al., ).Cited by: 5.

It is thought that after an initial activation signal, e.g., by antigen or anti-Ig, receptors for BSF and other growth and differentiation factors are expressed, and that in the presence of these factors B cells divide and mature into antibody-forming cells (4–6).Cited by: 1.

Reactive oxygen species (ROS) induce nuclear factor erythroid 2–related factor 2 (Nrf2) activation as an adaptive defense mechanism, determining the synthesis of antioxidant molecules, including heme-oxygenase-1 (HO-1). HO-1 protects cells against oxidative injury, degrading free heme and inhibiting ROS production.

HO-1 is highly expressed in macrophages during plaque by: 3. In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology and its subdisciplines are traditionally done in labware such as test tubes, flasks, Petri dishes, and microtiter s conducted using components of an organism.

Abstract. Drug induced liver injury (DILI) is still the leading single cause of drug failure during clinical phases and after market approval. Currently, many laboratories aim to develop appropriate in vitro systems to predict drug hepatotoxicity.

Primary human hepatocytes are still the gold standard, but they have substantial disadvantages such as rapid Cited by: 4. The effect of glioma cells in augmenting BV-2 murine microglia motility was studied by using an in vitro Boyden chamber migration assay.

To determine the chemokines involved in microglia migration, neutralizing monoclonal antibodies against monocyte chemotactic protein-1 and HGF/SF were by: The effect of biomaterial topography on healing in vivo and monocyte/macrophage stimulation in vitro was assessed. A series of expanded polytetrafluoroethylene (ePTFE) materials were characterized by increasing average intranodal distance of µm (ePTFE), µm (ePTFE) and µm (ePTFE), but presented consistent surface chemistry with nonporous Cited by:   Regulatory Mechanisms in Lymphocyte Activation covers the proceedings of the 11th Leukocyte Culture Conference, held at the Arizona Medical Center, University of Arizona on SeptemberStudies on the Human T Lymphocyte—Sheep Erythrocyte Receptor The Toxicity of Cyclophosphamide for T and B Cells In Vitro Growth of Canine.

Abstract. Studies of anticancer therapies in traditional cell culture models can demonstrate efficacy of direct-acting compounds but lack the 3-dimensional arrangement of the tumor cells and their tissue-specific microenvironments, both of which are important modulators of treatment effects in cells reside in complex environments that regulate their fate and Author: Courtney Sakolish, John S House, Alan Chramiec, Yizhong Liu, Zunwei Chen, Susan P Halligan, Gordana.

The cornerstone of Evotec’s in vitro biology function is disease and target biology expertise coupled with state-of-the-art technology platforms. A large team of > scientists with extensive industrial experience supports the in vitro pharmacological characterisation of compounds as part of hit expansion, lead finding and lead optimisation projects, generating project-relevant high.

Iacobelli M, Rohwer F, Shanahan P, Quiroz JA, McGuire KL. ILmediated cell cycle progression and inhibition of apoptosis does not require NF-kappa B or activating protein-1 activation in primary human T cells.

J Immunol ; Taken together, to the best of our knowledge, this is the first report that Sig-1R activation (a) enhances the autophagic flux in human cells and in C. elegans, and (b) has positive effects on proteostasis. We described a novel activity of the compound ANAVEX having dual selective Sig-1R/muscarinic activities in by: 4.

Embryonic stem cells have important applications in biomedical research Basic studies of early human development and its disorders-birth defects, childhood cancers Functional genomics in human cells Discovery of novel factors controlling tissue regeneration and repair In vitro models for drug discovery and toxicologyFile Size: 1MB.

Abstract Objective: Vitamin D (VitD) is an anti-inflammatory hormone; however, some evidence shows that VitD may induce the expression of activation markers, such as CD38 and HLA-DR. We explored its effect on the expression of these markers on CD4+ and CD8+ T-cells in vitro, and their potential correlations in vivo.

Materials and methods: CD38 and HLA Cited by: 1. @article{osti_, title = {Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro}, author = {Rubin, L.A. and Kurman, C.C. and Fritz, M.E. and Biddison, W.E.

and Boutin, B. and Yarchoan, R. and Nelson, D.L.}, abstractNote = {With the use of an enzyme-linked immunoabsorbent assay to measure soluble human interleukin 2 receptors (IL .AID-directed SHM in vitro in non-B cells, combined with mammalian display of a library of human antibodies, initially naïve to SHM, can be used to isolate and affinity mature antibodies via.Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro.

We have developed bacterial expression and purification systems for Cdk2 and cyclin A that allow mechanistic studies of the activation process to be performed in the absence of cell extracts.

Molecular Biology of the Cell is published by the.